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Insulin-Mediated Glucose Uptake
The molecular mechanisms of insulin-mediated glucose transport are intensively studied – GLUT4 (glucose transporter type 4) is really a glucose transporter accountable for glucose uptake into adipocytes and muscle tissues
Importantly, in situation of insulin resistance and kind-2, the quantity of GLUT4 is decreased and it is translocation is impaired
https://world wide web.hindawi.com/journals/omcl/2019/3849692/
Insulin resistance is characterised by inefficient mitochondrial coupling, low-level of ATP, and also the formation of excess quantity of ROS
Research printed within the Journal of Cachexia, Sarcopenia and Muscle, implies that astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK path*
Astaxanthin accumulation in skeletal muscle continues to be proven to lessen hyperglycemia and improve insulin secretion and sensitivity by improvement of glucose metabolic process and β-cell disorder by GLUT4 regulation
Astaxanthin administration boosts the translocation of GLUT4 transporter and PGC-1α, which increases the amount of GLUT4
Study – Asia Off-shore Clinical Diet
This double blind, randomized, placebo controlled study incorporated 41 patients varying from 30 to 60 years old with diabetes type 2 who weren’t on insulin therapy.
Each patient consumed 8 mg of astaxanthin or placebo daily for 8 days. Consequently, the astaxanthin group shown a rise in adiponectin concentration and reduced visceral excess fat, triglycerides, Cholestrerol levels, and systolic bloodstream pressure.
https://world wide web.ncbi.nlm.nih.gov/pubmed/29384321
https://world wide web.ncbi.nlm.nih.gov/pubmed/12688512
Zinc ions can bind to insulin receptors and activate insulin signaling pathways
Thought that zinc ions hinder glycogen synthase kinase-3beta (GSK-3beta), serine/threonine protein kinase associated with insulin resistance and diabetes type 2
https://world wide web.ncbi.nlm.nih.gov/pubmed/12083774
Study – Journal of Diabetes
Following a year, 25% from the placebo group developed diabetes type 2 as well as the zinc group, 11 percent developed diabetes type 2.
The zinc group also were built with a lower fasting plasma glucose, dental glucose tolerance test, homeostatic model assessment of insulin resistance in addition to lower scores for total and Cholestrerol levels. There is also “significant improvement” in beta cell function observed in the zinc group
Zinc in pancreatic beta cells binds to many insulin molecules, six to become exact, developing what’s known as an insulin hexamer for storage – insulin is created and stored in your body like a hexamer (one of six insulin molecules)
In the existence of insulin, the chromodulin molecule changes shape and placement within the cell, triggering activation of the vital glucose transporter molecule known as GLUT4
Study – The Worldwide Journal for Vitamin and Diet Research
This research investigated the results of chromium picolinate on seniors diabetics inside a rehabilitation program.
https://world wide web.ncbi.nlm.nih.gov/pubmed/15296075
Research in the journal Diabetes discovered that lithium increases in glucose transport activity and results in a modest rise in insulin responsiveness
Even though the authors concluded, “the results of lithium on glucose transport and metabolic process in skeletal muscle are strikingly like the persistent results of exercise. These results support the chance that lithium may be helpful in treating insulin resistance in patients with non-insulin-dependent diabetes.”
When skeletal muscle groups are given lithium, the amount of cell surface GLUT4 protein contents are elevated
https://world wide web.jstage.jst.go.jp/article/jnsv/63/6/63_365/_pdf
https://world wide web.ncbi.nlm.nih.gov/pubmed/29332897